The story is set in near-future Japan where a mysterious new drug called "DOPE" is spreading. Rookie narcotics agent Yuto Saiki gets unexpectedly transferred to a highly confidential division - the Special Investigations Division of the Narcotics Control Department. There, he's paired with his polar opposite, the gruff veteran agent Teppei Jinnai, who makes a terrible first impression. Despite their clashing personalities, these incompatible partners must work together with other unique members of the Special Investigations Division to solve bizarre cases caused by DOPE. However, all team members harbor "unspoken secrets" that add complexity to their missions...